REDCap

Intervention trials

This searchable database contains the latest intervention studies approved by the LSHTM Research Ethics Committee, along with historical data from the Research Governance and Integrity Office. You can search using keywords and filters to find relevant information, with results sorted in descending order by the review status date of projects. Please note, only projects approved from 2018 onward will appear in your search results. For any questions or assistance, feel free to contact our team at [email protected].

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Returned 334 projects out of 334

Bringing Down Hurdles for Female Genital Schistosomiasis Access to Care: A Multi-Country Socio-Structural Integrated Approach to Developing A Community-Based Teaching Platform Faculty or Unit of Lead Investigator Public Health and Policy (PHP) Project type Trial of a public health intervention (eg behavioural, education) Malawi,United Republic of Tanzania,Zambia
An open label, Phase 2 study to evaluate the safety and immunogenicity of an Ad26.ZEBOV booster dose in Human Immunodeficiency Virus Positive (HIV+) adults previously vaccinated with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Kenya,Uganda
Cluster randomised controlled trial of a complex intervention package to reduce blindness from severe microbial keratitis in Uganda Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Other interventional trial Uganda
Cluster randomised controlled trial of a complex intervention package to reduce blindness from severe microbial keratitis in Nepal Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Other interventional trial Nepal
A multi-centre, randomised, controlled non-inferiority trial to compare the efficacy, safety and tolerability of Triple Artemisinin-based Combination Therapies versus firstline ACTs + placebo for the Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) The Gambia,Burkina Faso,Democratic Republic of Congo,Guinea,Niger,Nigeria,United Republic of Tanzania,Rwanda
The Potential of Online Networks to Initiate Social Norms Change in Offline Communities During COVID-19: A Mixed Methods Study in Nairobi, Kenya Faculty or Unit of Lead Investigator Public Health and Policy (PHP) Project type Other interventional trial Kenya
A Phase 1 Trial of ChAdOx1- and MVA-vectored Conserved Mosaic HIV-1 Vaccines in Healthy, Adult HIV-1-negative Volunteers in Eastern and Southern Africa Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda,Kenya,Zambia
A multicenter, phase III, double-blind, randomized, active-controlled study to evaluate the efficacy and safety of VPM1002 in comparison to BCG in prevention of TB infection in newborn infants (priMe) Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda,Gabon,South Africa,United Republic of Tanzania,Kenya
Pharmacokinetics and tolerability of Adjunctive Linezolid for the Treatment of tuberculous meningitis (ALTER): a Phase II trial, open-label, randomized trial Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda
Establishing a Single-sex Controlled Human Schistosoma mansoni Infection Model for Uganda: safety and dose finding Faculty or Unit of Lead Investigator MRC Uganda Project type Other interventional trial Uganda
A Phase III randomized controlled multi-centre trial to evaluate the efficacy of the R21/Matrix-M vaccine in African children against clinical malaria Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) United Kingdom,Burkina Faso,Kenya,Mali,United Republic of Tanzania
Laser treatment for glaucoma in Nigeria: Feasibility study of four different treatment modalities to provide data to design randomised controlled trials Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Other interventional trial Nigeria
Evaluation of High Dose Rifampicin and Dialkylcarbamoyl chloride (DACC)-coated dressings to improve outcomes in Mycobacterium ulcerans disease Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Ghana
IMPRESS: Innovative Management PRactices to Enhance hoSpital quality and Save lives in Malawi. New title: A cluster randomised trial of the impact of a multi-faceted hospital management intervention on in-hospital mortality and the quality of clinical care for small and sick newborns in Malawi. Faculty or Unit of Lead Investigator Public Health and Policy (PHP) Project type Trial of a public health intervention (eg behavioural, education) Malawi
Surprise Soaps; further piloting in humanitarian contexts Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Trial of a public health intervention (eg behavioural, education) Somalia,Sudan
Hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; a randomised, placebo-controlled prophylaxis study (COPCOV) Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Zambia,United Kingdom,Thailand,Cambodia,India,Mali,Kenya,Guinea,Ghana,The Gambia,Ethiopia,Egypt,Democratic Republic of Congo,Cote D'Ivoire,Cameroon,Burkina Faso,Botswana,Benin,Vietnam,Sudan,South Africa,Sierra Leone,Senegal,Nigeria,Niger,Mozambique,United Republic of Tanzania,Zimbabwe,Uganda,Tunisia,Ukraine,Switzerland,Russia,Netherlands,Italy,France,Croatia,Bangladesh,Indonesia,Nepal,Maldives,Pakistan,Saudi Arabia,Argentina,Brazil,Canada,Chile,Colombia,Jamaica,Dominican Republic,Guatemala,Malaysia,Cuba,Peru
Improving health systems responsiveness to neglected health needs of vulnerable groups in Ghana and Vietnam Faculty or Unit of Lead Investigator Public Health and Policy (PHP) Project type Other interventional trial Ghana,Vietnam
Intramuscular tranexamic acid for the treatment of symptomatic mild traumatic brain injury in older adults: a randomised, double-blind, placebo-controlled trial Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) United Kingdom
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda
Adherence Support Coalition to End TB: four-country evaluation of digital adherence technologies for TB treatment Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Trial of a public health intervention (eg behavioural, education) Philippines,South Africa,United Republic of Tanzania,Ukraine