REDCap

Intervention trials

This searchable database contains the latest intervention studies approved by the LSHTM Research Ethics Committee, along with historical data from the Research Governance and Integrity Office. You can search using keywords and filters to find relevant information, with results sorted in descending order by the review status date of projects. Please note, only projects approved from 2018 onward will appear in your search results. For any questions or assistance, feel free to contact our team at [email protected].

Clinical trial of an investigational medicinal product (eg drugs)

Returned 97 projects out of 331

Implementing oral (event-driven and daily) and long-acting Pre-Exposure Prophylaxis in mobile men in Sub-Saharan Africa: a phase 3b, open-label, hybrid type 2 implementation and effectiveness trial (M Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Uganda,South Africa
Effect of single-course malaria chemoprevention on clearance of and protection from Plasmodium falciparum infection in the presence of resistance-associated genotypes in Zambia Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Zambia
EuNmCV-5 vaccine trial, The Gambia Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III The Gambia,Mali,United Kingdom,Italy
Effect of single-course malaria chemoprevention on clearance of and protection from Plasmodium falciparum infection in the presence of resistance-associated genotypes in Cameroon Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Cameroon,Denmark,United Kingdom
Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, phase 1/2a trial in malaria-exposed Malian adults and children Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase I/II Mali
A Phase 1 Clinical Study to Evaluate the Safety and Immunogenicity of a Novel GMMA Vaccine Against Invasive Non-Typhoidal Salmonella in healthy Kenyan adults. Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase I Kenya
A Confirmatory Trial of Adjunctive N-acetylcysteine (NAC) to Prevent and/or Treat Post Tuberculosis Lung Disease (PTLD) Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III The Gambia,United Republic of Tanzania,Mozambique,South Africa,Germany
Evaluating the effectiveness and cost-effectiveness of integrating mass drug administration for helminth control with seasonal malaria chemoprevention in Ghanaian children Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Not applicable Ghana,United Kingdom
The TopCAT Trial - A randomised controlled trial investigating the survival benefit of adding Topotecan/Cyclophosphamide to standard chemotherapy for Advanced Retinoblastoma in Tanzania Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II United Republic of Tanzania
Phase 2a Multicenter, Randomized Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of M5717-pyronaridine as Chemoprevention in Asymptomatic individuals with P. falciparum Infection Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II The Gambia,Zambia,Burkina Faso
The impact of a combination of the RTS,S/AS01e malaria vaccine and perennial malaria chemoprevention in Ghanaian children Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Ghana
A Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the blood-stage malaria vaccine candidates RH5.1 in Matrix-MTM and RH5.2-VLP in Matrix-MTM in infants aged 5-17 mo Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II United Kingdom,Burkina Faso
Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised, double-blind, placebo-controlled trial Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Pakistan,Nigeria,United Republic of Tanzania,United Kingdom
A Phase Ib study of a multi-stage Plasmodium falciparum vaccine candidate in adults and infants in The Gambia Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) The Gambia
Efficacy, Safety and Effectiveness of Injectable Cabotegravir/Rilpivirine in Improving HIV-1 Control in sub-Saharan Africa: A Pragmatic Phase 3b Open-Label Randomized Controlled Trial Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Uganda
VAC092 - A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-MTM in African children living with HIV Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda
A phase Ib study to assess the safety and immunogenicity of a recombinant adenovirus-based vaccine against plague in Uganda Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda
A five-arm trial comparing artesunate-amodiaquine and artemether-lumefantrine-amodiaquine with or without single-dose primaquine to reduce P. falciparum transmission in Mali Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Mali
Clinical trial of Ashwagandha for promoting recovery from COVID-19 in the UK Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III United Kingdom
Phase 3, Serum Institute of India, Infant Yellow Fever Vaccine Trial Faculty or Unit of Lead Investigator MRC Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Gambia,Mali,Italy,United Kingdom,India