REDCap

Intervention trials

This searchable database contains the latest intervention studies approved by the LSHTM Research Ethics Committee, along with historical data from the Research Governance and Integrity Office. You can search using keywords and filters to find relevant information, with results sorted in descending order by the review status date of projects. Please note, only projects approved from 2018 onward will appear in your search results. For any questions or assistance, feel free to contact our team at [email protected].

Clinical trial of an investigational medicinal product (eg drugs)

Returned 110 projects out of 383

A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of MK-8527 Oral Once-Monthly as HIV-1 Preexposure Prophylaxis in Women Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Uganda
RADIO-TB - Optimal management of radiographically apparent, bacteriologically unconfirmed TB identified through active case finding Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Pakistan,Zimbabwe,South Africa,United Kingdom
A Phase 2, Randomized, Open-label, Active Controlled Study to Evaluate the Safety, Tolerability and Immunogenicity of Measles and Rubella Vaccine Microneedle Patches in Healthy Infants, in The Gambia. Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II The Gambia,United States of America
MARGUERITE: A PHASE 3 STUDY OF REVACCINATION IN SUBSEQUENT PREGNANCIES WITH RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE AND DURATION OF PROTECTION OF A SINGLE DOSE Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III The Gambia,South Africa,United States of America,Argentina
A Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the malaria vaccine candidates R78C with Matrix-M™, and the combination of RH5.1 and R21 with Matrix-M™. Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II United Kingdom,Burkina Faso
A study to evaluate safety, reactogenicity, and immune response of GVGH iNTS-TCV vaccine against invasive nontyphoidal Salmonella disease and Typhoid Fever in infants Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II The Gambia,Italy
ValgaNciclovIR for CMV Viraemia in AdvaNced HIV diseAse A phase 2b Randomised Placebo Controlled Trial of Valganciclovir for Cytomegalovirus Viraemia in adults and adolescents with Advanced HIV Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II Uganda,South Africa
CARES-1: Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase II Malawi,United Kingdom,South Africa,Indonesia,Australia,Thailand,Ireland
A phase III Randomized Placebo Controlled Study to Assess Efficacy and Safety of Crizanlizumab versus placebo in Adolescent and Adult Sickle Cell Disease Patients with Frequent Vaso-Occlusive Crises Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Uganda
A Phase 1b, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Mosquitocidal Activity of Single Oral Doses of Lotilaner in Healthy Participants in West Africa Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase I Mali
A Phase 4, Open-Label, Cabotegravir + Rilpivirine Long-Acting Injection Rollover Study Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Uganda,Kenya,South Africa
Population-pharmacokinetics, safety and tolerability of sustained-release flucytosine pellets for the treatment of asymptomatic cryptococcal antigen-positive individuals: a single-arm trial Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) South Africa
The effects of tranexamic acid on anaemia, menstrual health and the wellbeing of women: an international randomised, placebo-controlled trial among menstruating women with anaemia Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Nigeria,Pakistan,United Republic of Tanzania,United Kingdom,France
Implementing oral (event-driven and daily) and long-acting Pre-Exposure Prophylaxis in mobile men in Sub-Saharan Africa: a phase 3b, open-label, hybrid type 2 implementation and effectiveness trial (M Faculty or Unit of Lead Investigator MRC Uganda Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Uganda,South Africa
Effect of single-course malaria chemoprevention on clearance of and protection from Plasmodium falciparum infection in the presence of resistance-associated genotypes in Zambia Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Zambia
EuNmCV-5 vaccine trial, The Gambia Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III The Gambia,Mali,United Kingdom,Italy
Effect of single-course malaria chemoprevention on clearance of and protection from Plasmodium falciparum infection in the presence of resistance-associated genotypes in Cameroon Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III Cameroon,Denmark,United Kingdom
Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, phase 1/2a trial in malaria-exposed Malian adults and children Faculty or Unit of Lead Investigator Infectious and Tropical Diseases (ITD) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase I/II Mali
A Phase 1 Clinical Study to Evaluate the Safety and Immunogenicity of a Novel GMMA Vaccine Against Invasive Non-Typhoidal Salmonella in healthy Kenyan adults. Faculty or Unit of Lead Investigator Epidemiology and Population Health (EPH) Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase I Kenya
A Confirmatory Trial of Adjunctive N-acetylcysteine (NAC) to Prevent and/or Treat Post Tuberculosis Lung Disease (PTLD) Faculty or Unit of Lead Investigator MRC The Gambia Project type Clinical trial of an investigational medicinal product (eg drugs) Randomised controlled trial Phase III The Gambia,United Republic of Tanzania,Mozambique,South Africa,Germany